BD-PT3756

PKC β Rabbit Polyclonal Antibody

PRKCB; PKCB; PRKCB1; Protein kinase C beta type; PKC-B; PKC-beta

常规抗体

PRKCB

Protein kinase C beta type

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

5579

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5579

P05771

http://www.uniprot.org/uniprotkb/P05771/entry

18751

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18751

P68404

http://www.uniprot.org/uniprot/P68404

25023

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25023

P68403

http://www.uniprot.org/uniprot/P68403

The antiserum was produced against synthesized peptide derived from human PKCB. AA range:622-671

PKC β Polyclonal Antibody detects endogenous levels of PKC β protein.

WB 1:500 - 1:2000. ELISA: 1:40000.. IF 1:50-200

77kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stres

Fetal brain,Hippocampus,Platelet,

Cytoplasm . Nucleus . Membrane ; Peripheral membrane protein .

Regulation_Microtubule; Regulation of Actin Dynamics; Stem cell pathway; Insulin Receptor; ErbB/HER; MAPK_ERK_Growth;MAPK_G_Protein; WNT;WNT-T CELL;β-Catenin; B Cell Receptor; NF_kappaB; mTOR; AMPK

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domain.,function:This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking.,PTM:Phosphorylation on Thr-500 of isoform beta-I, within the activation loop, renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Similarly, isoform beta-II is autophosphorylated on 'Thr-640' and 'Ser-659', subsequent to phosphorylation on Thr-500. Autophosphorylated on other sites i.e. in the N-terminal and hinge regions have no effect on PKC activity.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.