BD-PT3750

PKAβ cat Rabbit Polyclonal Antibody

PRKACB; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta

常规抗体

PRKACB

cAMP-dependent protein kinase catalytic subunit beta

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

5567

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5567

P22694

http://www.uniprot.org/uniprotkb/P22694/entry

18749

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18749

P68181

http://www.uniprot.org/uniprot/P68181

293508

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=293508

P68182

http://www.uniprot.org/uniprot/P68182

The antiserum was produced against synthesized peptide derived from human KAPCB. AA range:291-340

PKAβ cat Polyclonal Antibody detects endogenous levels of PKAβ cat protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

53kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014],

Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.

Cytoplasm . Cell membrane . Membrane ; Lipid-anchor . Nucleus . Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. .

MAPK_ERK_Growth;MAPK_G_Protein;Calcium;Chemokine;Oocyte meiosis;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Vascular smooth muscle contraction;WNT;WNT-T CELLHedgehog;Gap junction;Long-term potentiation;Olfactory transduction;Taste tran

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by cAMP.,function:Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.,PTM:Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.,subunit:A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.,tissue specificity:Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoforms 3 and 4 are only epxressed in the brain.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.