产品名称
PIXβ Rabbit Polyclonal Antibody
别名
ARHGEF7; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB; Nbla10314; Rho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85
蛋白名称
Rho guanine nucleotide exchange factor 7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8874
Human Swissprot No.
Q14155
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14155/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54126
Mouse Swissprot No.
Q9ES28
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9ES28
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114559
Rat Swissprot Link
http://www.uniprot.org/uniprot/O55043
免疫原
The antiserum was produced against synthesized peptide derived from human ARHGEF7. AA range:311-360
特异性
PIXβ Polyclonal Antibody detects endogenous levels of PIXβ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016],
组织表达
Amygdala,Bone marrow,Brain,Epithelium,Neuroblastoma,Testis,
细胞定位
Cell junction, focal adhesion . Cell projection, ruffle . Cytoplasm, cell cortex . Cell projection, lamellipodium . Detected at cell adhesions. A small proportion is detected at focal adhesions.
信号通路
Regulation of Actin Dynamics; AMPK
功能
function:Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with ITCH (By similarity). Interacts with unphosphorylated PAK1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
