产品名称
PIG-X Rabbit Polyclonal Antibody
别名
PIGX; Phosphatidylinositol-glycan biosynthesis class X protein; PIG-X
蛋白名称
Phosphatidylinositol-glycan biosynthesis class X protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54965
Human Swissprot No.
Q8TBF5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8TBF5/entry
Mouse Swissprot No.
Q99LV7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99LV7
免疫原
The antiserum was produced against synthesized peptide derived from human PIGX. AA range:183-232
特异性
PIG-X Polyclonal Antibody detects endogenous levels of PIG-X protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
细胞定位
Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
信号通路
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;
功能
function:Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.,pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.,PTM:N-glycosylated.,sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.,similarity:Belongs to the PIGX family.,subunit:Interacts with PIGM.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
