产品名称
XYLT1 Rabbit Polyclonal Antibody
别名
Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.253% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64131
Human Swissprot No.
Q86Y38
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86Y38/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/233781
Mouse Swissprot No.
Q811B1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q811B1
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EPI1
免疫原
Synthesized peptide derived from human XYLT1 AA range: 312-362
特异性
This antibody detects endogenous levels of XYLT1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009],
组织表达
Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle.
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein . Secreted . Detected predominantly in the Golgi apparatus. .
功能
catalytic activity:Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate.,cofactor:Divalent cations.,function:Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.,miscellaneous:Activity is strongly reduced in seminal plasma of unfertile men.,online information:GlycoGene database,pathway:Glycan metabolism; chondroitin sulfate biosynthesis.,pathway:Glycan metabolism; heparan sulfate biosynthesis.,PTM:Contains 7 disulfide bonds.,PTM:N-glycosylated.,similarity:Belongs to the glycosyltransferase 14 family. XylT subfamily.,subcellular location:Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted.,subunit:Monomer.,tissue specificity:Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
