产品名称
PHKG1 Rabbit Polyclonal Antibody
别名
PHKG1; PHKG; Phosphorylase b kinase gamma catalytic chain; skeletal muscle isoform; Phosphorylase kinase subunit gamma-1
蛋白名称
Phosphorylase b kinase gamma catalytic chain skeletal muscle isoform
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5260
Human Swissprot No.
Q16816
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16816/entry
Mouse Swissprot No.
P07934
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P07934
免疫原
The antiserum was produced against synthesized peptide derived from human PHKG1. AA range:241-290
特异性
PHKG1 Polyclonal Antibody detects endogenous levels of PHKG1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012],
组织表达
PCR rescued clones,Salivary gland,Skeletal muscle,
细胞定位
cytosol,phosphorylase kinase complex,
信号通路
Calcium;Insulin_Receptor;
功能
catalytic activity:2 ATP + phosphorylase b = 2 ADP + phosphorylase a.,domain:The two calmodulin-binding domains appear to act in concert to bind a single molecule of calmodulin and are pseudosubstrate/autoinhibitory domains.,function:Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Polymer of 16 chains, four each of alpha, beta, gamma, and delta. Alpha and beta are regulatory chains, gamma is the catalytic chain, and delta is calmodulin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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