产品名称
PGI2 synthase Rabbit Polyclonal Antibody
别名
PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase
蛋白名称
Prostacyclin synthase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5740
Human Swissprot No.
Q16647
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16647/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19223
Mouse Swissprot No.
O35074
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35074
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25527
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q62969
免疫原
Synthesized peptide derived from the C-terminal region of human PGI2 synthase.
特异性
PGI2 synthase Polyclonal Antibody detects endogenous levels of PGI2 synthase protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein .
信号通路
Arachidonic acid metabolism;
功能
catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.,cofactor:Heme group.,function:Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).,online information:CYP8A1 alleles,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
