产品名称
PGE synthase Rabbit Polyclonal Antibody
别名
PTGES; MGST1L1; MPGES1; PGES; PIG12; Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
蛋白名称
Prostaglandin E synthase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9536
Human Swissprot No.
O14684
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14684/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64292
Mouse Swissprot No.
Q9JM51
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JM51
免疫原
The antiserum was produced against synthesized peptide derived from human PGE synthase. AA range:30-79
特异性
PGE synthase Polyclonal Antibody detects endogenous levels of PGE synthase protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
prostaglandin E synthase(PTGES) Homo sapiens The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008],
组织表达
Breast,Colon cancer,Pancreas,
细胞定位
Membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. .
信号通路
Arachidonic acid metabolism;
功能
catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.,induction:By TP53/p53.,similarity:Belongs to the MAPEG family.,subunit:Homotrimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
