产品名称
PFK-B Rabbit Polyclonal Antibody
别名
PFKL; 6-phosphofructokinase; liver type; Phosphofructo-1-kinase isozyme B; PFK-B; Phosphofructokinase 1; Phosphohexokinase
蛋白名称
6-phosphofructokinase liver type
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5211
Human Swissprot No.
P17858
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P17858/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18641
Mouse Swissprot No.
P12382
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P12382
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25741
Rat Swissprot Link
http://www.uniprot.org/uniprot/P30835
免疫原
The antiserum was produced against synthesized peptide derived from human K6PL. AA range:691-740
特异性
PFK-B Polyclonal Antibody detects endogenous levels of PFK-B protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],
组织表达
Brain,Cervix,Colon,Human amygdala,Human retina,Kidney,Liver,Lung,Muscle,Pla
信号通路
Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;Galactose metabolism;
功能
catalytic activity:ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.,cofactor:Magnesium.,enzyme regulation:Allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate.,miscellaneous:In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.,similarity:Belongs to the phosphofructokinase family. Two domains subfamily.,subunit:Tetramer. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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