产品名称
PFK-2 liv Rabbit Polyclonal Antibody
别名
PFKFB1; F6PK; PFRX; 6-phosphofructo-2-kinase/fructose-2; 6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme
蛋白名称
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5207
Human Swissprot No.
P16118
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P16118/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18639
Mouse Swissprot No.
P70266
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70266
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24638
Rat Swissprot Link
http://www.uniprot.org/uniprot/P07953
免疫原
The antiserum was produced against synthesized peptide derived from human PFKFB1. AA range:406-455
特异性
PFK-2 liv Polyclonal Antibody detects endogenous levels of PFK-2 liv protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012],
细胞定位
cytosol,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex,
信号通路
Fructose and mannose metabolism;
功能
catalytic activity:ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.,catalytic activity:Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.,enzyme regulation:Phosphorylation results in inhibition of the kinase activity.,function:Synthesis and degradation of fructose 2,6-bisphosphate.,similarity:In the C-terminal section; belongs to the phosphoglycerate mutase family.,subunit:Homodimer.,tissue specificity:Liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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