产品名称
RBM19 Rabbit Polyclonal Antibody
别名
Probable RNA-binding protein 19 (RNA-binding motif protein 19)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.254% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9904
Human Swissprot No.
Q9Y4C8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y4C8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/74111
Mouse Swissprot No.
Q8R3C6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R3C6
免疫原
Synthesized peptide derived from human RBM19 AA range: 276-326
特异性
This antibody detects endogenous levels of RBM19 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Apr 2009],
组织表达
Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level).
细胞定位
Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm . Chromosome . In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB. .
功能
similarity:Belongs to the RRM MRD1 family.,similarity:Contains 6 RRM (RNA recognition motif) domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
