BD-PT3661

Pepsin C Rabbit Polyclonal Antibody

PGC; Gastricsin; Pepsinogen C

常规抗体

PGC

Gastricsin

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

5225

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5225

P20142

http://www.uniprot.org/uniprotkb/P20142/entry

Q9D7R7

http://www.uniprot.org/uniprot/Q9D7R7

The antiserum was produced against synthesized peptide derived from human Pepsin C. AA range:257-306

Pepsin C Polyclonal Antibody detects endogenous levels of Pepsin C protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

42kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009],

Brain,Liver,Placenta,Stomach,

Secreted.

catalytic activity:More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.,function:Hydrolyzes a variety of proteins.,similarity:Belongs to the peptidase A1 family.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.