产品名称
PDK1 Rabbit Polyclonal Antibody
别名
PDK1; PDHK1; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; mitochondrial; Pyruvate dehydrogenase kinase isoform 1
蛋白名称
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1 mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5163
Human Swissprot No.
Q15118
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15118/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=228026
Mouse Swissprot No.
Q8BFP9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BFP9
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63065
免疫原
Synthesized peptide derived from PDK1 . at AA range: 80-160
特异性
PDK1 Polyclonal Antibody detects endogenous levels of PDK1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013],
组织表达
Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas.
细胞定位
Mitochondrion matrix .
信号通路
T_Cell_Receptor;Fc epsilon RI;Neurotrophin;
功能
catalytic activity:ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.,function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.,similarity:Belongs to the PDK/BCKDK protein kinase family.,similarity:Contains 1 histidine kinase domain.,tissue specificity:Expressed predominantly in the heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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