产品名称
PDGF-A Rabbit Polyclonal Antibody
别名
PDGFA; PDGF1; Platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
蛋白名称
Platelet-derived growth factor subunit A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5154
Human Swissprot No.
P04085
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P04085/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18590
Mouse Swissprot No.
P20033
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P20033
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25266
Rat Swissprot Link
http://www.uniprot.org/uniprot/P28576
免疫原
The antiserum was produced against synthesized peptide derived from human PDGF-A. AA range:105-154
特异性
PDGF-A Polyclonal Antibody detects endogenous levels of PDGF-A protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
platelet derived growth factor subunit A(PDGFA) Homo sapiens This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
细胞定位
Secreted. Released by platelets upon wounding.
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cytokine-cytokine receptor interaction;Focal adhesion;Gap junction;Regulates Actin and Cytoskeleton;Pathways in cancer;Glioma;Prostate cancer;Melanoma;
功能
domain:The long form contains a basic insert which acts as a cell retention signal.,function:Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.,miscellaneous:A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.,similarity:Belongs to the PDGF/VEGF growth factor family.,subunit:Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
