产品名称
PDE4C Rabbit Polyclonal Antibody
别名
PDE4C; DPDE1; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4C; DPDE1; PDE21
蛋白名称
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5143
Human Swissprot No.
Q08493
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q08493/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=110385
Mouse Swissprot No.
Q3UEI1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UEI1
Rat Swissprot Link
http://www.uniprot.org/uniprot/P14644
免疫原
The antiserum was produced against synthesized peptide derived from human PDE4C. AA range:291-340
特异性
PDE4C Polyclonal Antibody detects endogenous levels of PDE4C protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],
组织表达
Expressed in various tissues but not in cells of the immune system.
细胞定位
Cell projection, cilium .
功能
catalytic activity:Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.,enzyme regulation:Inhibited by rolipram.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,tissue specificity:Expressed in various tissues but not in cells of the immune system.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
