产品名称
PDE4B/C/D Rabbit Polyclonal Antibody
别名
PDE4B; DPDE4; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4B; DPDE4; PDE32; PDE4C; DPDE1; cAMP-specific 3',5'-cyclic phosphodiesterase 4C; DPDE1; PDE21; PDE4D; DPDE3; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; DPDE3; PDE43
蛋白名称
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
5144/5142/5143
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5144
Human Swissprot No.
Q07343/Q08493/Q08499
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q07343/entry
Mouse Gene ID
110385/238871
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=110385
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24626
Rat Swissprot No.
P14646/P14644/P14270
Rat Swissprot Link
http://www.uniprot.org/uniprot/P14646
免疫原
The antiserum was produced against synthesized peptide derived from human PDE4D. AA range:156-205
特异性
PDE4B/C/D Polyclonal Antibody detects endogenous levels of PDE4B/C/D protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],
组织表达
Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015). ; [Isoform PDE4B5]: Brain-specific isoform.
细胞定位
[Isoform PDE4B5]: Cytoplasm . Cell membrane .
功能
alternative products:Additional isoforms seem to exist,catalytic activity:Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.,enzyme regulation:Inhibited by rolipram.,function:May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,tissue specificity:Expressed in brain, heart, lung and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
.jpg)
