产品名称
P-cadherin Rabbit Polyclonal Antibody
别名
CDH3; CDHP; Cadherin-3; Placental cadherin; P-cadherin
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1001
Human Swissprot No.
P22223
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P22223/entry
Mouse Swissprot No.
P10287
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P10287
免疫原
The antiserum was produced against synthesized peptide derived from human CDH3. AA range:51-100
特异性
P-cadherin Polyclonal Antibody detects endogenous levels of P-cadherin protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015],
组织表达
Expressed in some normal epithelial tissues and in some carcinoma cell lines.
细胞定位
Cell membrane; Single-pass type I membrane protein.
信号通路
Cell adhesion molecules (CAMs);
功能
disease:Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM) [MIM:225280]; also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EEM is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.,disease:Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD) [MIM:601553]. HJMD is a rare autosomal recessive disorder characterized by early hair loss heralding severe degenerative changes of the retinal macula and culminating in blindness during the second to third decade of life.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,online information:Retina International's Scientific Newsletter,similarity:Contains 5 cadherin domains.,subunit:Interacts with CDCP1.,tissue specificity:Expressed in some normal epithelial tissues and in some carcinoma cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
