产品名称
PBR Rabbit Polyclonal Antibody
别名
TSPO; BZRP; MBR; Translocator protein; Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR
蛋白名称
Translocator protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=706
Human Swissprot No.
P30536
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P30536/entry
免疫原
Synthesized peptide derived from PBR . at AA range: 90-170
特异性
PBR Polyclonal Antibody detects endogenous levels of PBR protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012],
组织表达
Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.
细胞定位
Mitochondrion membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;
功能
protein targeting,?protein targeting to mitochondrion,?porphyrin metabolic process,?porphyrin biosynthetic process,heme biosynthetic process,?ion transport,?anion transport,?mitochondrial transport,?intracellular protein transport,apoptosis,?mitochondrion organization,?protein localization,?steroid metabolic process,?cell death,?cell proliferation,programmed cell death,?protein transport,?death,?protein import,?heterocycle biosynthetic process,?regulation of lipid transport,?regulation of sterol transport,?regulation of cholesterol transport,?tetrapyrrole metabolic process,tetrapyrrole biosynthetic process,?protein localization in organelle,?cellular protein localization,?heme metabolic process,?pigment metabolic process,?nitrogen compound biosynthetic process,?establishment of protein localization,pigment biosynthetic process,?intracellular transport,?cofactor metabolic process,?cofactor biosynthetic process,?protein localization in mitochondrion,?cellular macromolecule localization,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
