产品名称
Pax-9 Rabbit Polyclonal Antibody
别名
PAX9; Paired box protein Pax-9
蛋白名称
Paired box protein Pax-9
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5083
Human Swissprot No.
P55771
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P55771/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18511
Mouse Swissprot No.
P47242
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P47242
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362741
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q2L4T2
免疫原
The antiserum was produced against synthesized peptide derived from human Pax-9. AA range:158-207
特异性
Pax-9 Polyclonal Antibody detects endogenous levels of Pax-9 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3. [provided by RefSeq, Sep 2015],
功能
disease:Defects in PAX9 are a cause of oligodontia [MIM:604625]. It is a form of familial or selective tooth agenesis. Oligodontia is defined as the agenesis of 6 or more permanent teeth without associated systemic disorders. Agenesis of one or more teeth constitutes one of the most common developmental anomalies in man. Reported incidences vary from 1.6% to 9.6%, excluding third molar (Wisdom tooth) agenesis, which occurs in 20% of the population.,function:Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.,similarity:Contains 1 paired domain.,subunit:Interacts with KDM5B.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
