BD-PT3602-Pax-8 Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

Pax-8 Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT3602

产品名称

Pax-8 Rabbit Polyclonal Antibody

别名

PAX8; Paired box protein Pax-8

类别

常规抗体

基因名称

PAX8

蛋白名称

Paired box protein Pax-8

推荐应用

反应种属

Human,Mouse,Rat

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

7849

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7849

Human Swissprot No.

Q06710

Human Swissprot Link

http://www.uniprot.org/uniprotkb/Q06710/entry

Mouse Gene ID

18510

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18510

Mouse Swissprot No.

Q00288

Mouse Swissprot Link

http://www.uniprot.org/uniprot/Q00288

Rat Gene ID

81819

Rat Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81819

Rat Swissprot No.

P51974

Rat Swissprot Link

http://www.uniprot.org/uniprot/P51974

免疫原

The antiserum was produced against synthesized peptide derived from human Pax-8. AA range:145-194

特异性

Pax-8 Polyclonal Antibody detects endogenous levels of Pax-8 protein.

稀释度

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

预测分子量

62kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],

组织表达

Expressed in the excretory system, thyroid gland and Wilms tumors.

细胞定位

Nucleus.

信号通路

Pathways in cancer;Thyroid cancer;

功能

caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,developmental stage:In developing excretory system, during thyroid differentiation and in adult thyroid.,disease:Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.,function:Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.,similarity:Contains 1 paired domain.,tissue specificity:Expressed in the excretory system, thyroid gland and Wilms tumors.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of Pax-8 antibody in paraffin-embedded human lung carcinoma tissue.

Western blot analysis of lysate from HT-29 cells, using Pax-8 antibody.

Western Blot analysis of various cells using Pax-8 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit （SC-003,Inventbiotech,MN,USA）.

Immunohistochemical analysis of paraffin-embedded Human Amygdala. 1, Antibody was diluted at 1:100（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.