产品名称
Pax-2 Rabbit Polyclonal Antibody
别名
PAX2; Paired box protein Pax-2
蛋白名称
Paired box protein Pax-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5076
Human Swissprot No.
Q02962
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q02962/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18504
Mouse Swissprot No.
P32114
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P32114
免疫原
The antiserum was produced against synthesized peptide derived from human Pax-2. AA range:144-193
特异性
Pax-2 Polyclonal Antibody detects endogenous levels of Pax-2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014],
组织表达
Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.
功能
developmental stage:Mainly in fetal kidney and juvenile nephrogenic rests.,disease:Defects in PAX2 are the cause of renal-coloboma syndrome (RCS) [MIM:120330]; also known as papillorenal syndrome or optic nerve coloboma with renal disease. RCS is an autosomal dominant disease characterized by the association of renal hypoplasia, vesicoureteral reflux and dysplasia of the retina and optic disk.,disease:Defects in PAX2 may be responsible for isolated renal hypoplasia as observed in oligomeganephronia (OMN). OMN is a rare congenital and usually sporadic anomaly characterized by bilateral renal hypoplasia, with a reduced number of enlarged nephrons and without urinary tract abnormalities.,function:Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS.,similarity:Contains 1 paired domain.,tissue specificity:Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
