产品名称
PAR-6β Rabbit Polyclonal Antibody
别名
PARD6B; PAR6B; Partitioning defective 6 homolog beta; PAR-6 beta; PAR-6B
蛋白名称
Partitioning defective 6 homolog beta
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84612
Human Swissprot No.
Q9BYG5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9BYG5/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58220
Mouse Swissprot No.
Q9JK83
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JK83
免疫原
The antiserum was produced against synthesized peptide derived from human PARD6B. AA range:233-282
特异性
PAR-6β Polyclonal Antibody detects endogenous levels of PAR-6β protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008],
组织表达
Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.
细胞定位
Cytoplasm. Cell membrane . Cell junction, tight junction .
信号通路
Endocytosis;Tight junction;
功能
domain:The PDZ domain mediates interaction with MPP5.,domain:The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.,function:Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.,similarity:Belongs to the PAR6 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 pseudo-CRIB domain.,subunit:Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19.,tissue specificity:Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
