产品名称
PAK5 Rabbit Polyclonal Antibody
别名
PAK7; KIAA1264; PAK5; Serine/threonine-protein kinase PAK 7; p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7
蛋白名称
Serine/threonine-protein kinase PAK 7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57144
Human Swissprot No.
Q9P286
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9P286/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=241656
Mouse Swissprot No.
Q8C015
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C015
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=311450
Rat Swissprot Link
http://www.uniprot.org/uniprot/D4A280
免疫原
The antiserum was produced against synthesized peptide derived from human PAK7. AA range:661-710
特异性
PAK5 Polyclonal Antibody detects endogenous levels of PAK5 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],
组织表达
Predominantly expressed in brain.
细胞定位
Mitochondrion. Cytoplasm. Nucleus. Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
信号通路
ErbB_HER;Axon guidance;Focal adhesion;T_Cell_Receptor;Regulates Actin and Cytoskeleton;Renal cell carcinoma;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:The activated kinase acts on a variety of targets.,PTM:Autophosphorylated when activated by CDC42/p21.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1.,tissue specificity:Predominantly expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
.jpg)
