产品名称
PABP5 Rabbit Polyclonal Antibody
别名
PABPC5; PABP5; Polyadenylate-binding protein 5; PABP-5; Poly(A)-binding protein 5
蛋白名称
Polyadenylate-binding protein 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140886
Human Swissprot No.
Q96DU9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96DU9/entry
免疫原
The antiserum was produced against synthesized peptide derived from human PABPC5. AA range:184-233
特异性
PABP5 Polyclonal Antibody detects endogenous levels of PABP5 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010],
组织表达
Expressed in fetal brain and in a range of adult tissues.
细胞定位
Cytoplasm .; [Isoform 2]: Mitochondrion matrix . Co-fractionates with mtDNA and co-immunoprecipitates with the mitochondrial poly(A) polymerase.
功能
function:Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo.,similarity:Contains 4 RRM (RNA recognition motif) domains.,tissue specificity:Expressed in fetal brain and in a range of adult tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
