产品名称
PA26 Rabbit Polyclonal Antibody
别名
SESN1; PA26; SEST1; Sestrin-1; p53-regulated protein PA26
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27244
Human Swissprot No.
Q9Y6P5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y6P5/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140742
Mouse Swissprot No.
P58006
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P58006
免疫原
The antiserum was produced against synthesized peptide derived from human SESN1. AA range:271-320
特异性
PA26 Polyclonal Antibody detects endogenous levels of PA26 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
细胞定位
Nucleus . Cytoplasm .
功能
disease:Defects in SESN1 may be involved in heterotaxia. Heterotaxia is an aetiologically heterogeneous condition caused by an abnormal left-right axis formation, resulting in reversed left-right polarity of one or more organ systems.,function:Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth.,induction:Isoforms T2 and isoform T3 are induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a p53-dependent manner. Isoform T1 is not induced by p53.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the sestrin family.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
