BD-PT3496

p19 Rabbit Polyclonal Antibody

CDKN2D; Cyclin-dependent kinase 4 inhibitor D; p19-INK4d

常规抗体

CDKN2D

Cyclin-dependent kinase 4 inhibitor D

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1032

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1032

P55273

http://www.uniprot.org/uniprotkb/P55273/entry

Q60773

http://www.uniprot.org/uniprot/Q60773

The antiserum was produced against synthesized peptide derived from human CDKN2D. AA range:96-145

p19 Polyclonal Antibody detects endogenous levels of p19 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

18kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008],

Bone marrow,Muscle,Platelet,Thymus,

Nucleus . Cytoplasm .

Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;

function:Interacts strongly with CDK4 and CDK6 and inhibits them.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.