产品名称
p18 Rabbit Polyclonal Antibody
别名
CDKN2C; CDKN6; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
蛋白名称
Cyclin-dependent kinase 4 inhibitor C
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1031
Human Swissprot No.
P42773
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P42773/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12580
Mouse Swissprot No.
Q60772
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60772
免疫原
The antiserum was produced against synthesized peptide derived from human p18 INK. AA range:111-160
特异性
p18 Polyclonal Antibody detects endogenous levels of p18 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008],
组织表达
Highest levels found in skeletal muscle. Also found in pancreas and heart.
细胞定位
nucleus,cytoplasm,cytosol,
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能
disease:Defects in CDKN2C are involved in tumor formation.,function:Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,subunit:Heterodimer of p18 with CDK6.,tissue specificity:Highest levels found in skeletal muscle. Also found in pancreas and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
