BD-PT3491

p140Cap Rabbit Polyclonal Antibody

SRCIN1; KIAA1684; P140; SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap

常规抗体

SRCIN1

SRC kinase signaling inhibitor 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

80725

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80725

Q9C0H9

http://www.uniprot.org/uniprotkb/Q9C0H9/entry

56013

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56013

Q9QWI6

http://www.uniprot.org/uniprot/Q9QWI6

56029

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56029

Q9QXY2

http://www.uniprot.org/uniprot/Q9QXY2

The antiserum was produced against synthesized peptide derived from human SNIP. AA range:811-860

p140Cap Polyclonal Antibody detects endogenous levels of p140Cap protein.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

112kD

-20°C/1 year

Polyclonal, Rabbit,IgG

function:Delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. Also involved in calcium-dependent exocytosis from PC12 cells.,PTM:Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.,similarity:Belongs to the p140Cap family.,subcellular location:Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions.,subunit:Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas through its C-terminal domain.,

Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.

Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, presynapse . Cell junction, synapse, postsynapse . Cell junction, synapse, postsynaptic density . Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. .

function:Delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. Also involved in calcium-dependent exocytosis from PC12 cells.,PTM:Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.,similarity:Belongs to the p140Cap family.,subcellular location:Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions.,subunit:Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas through its C-terminal domain.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.