产品名称
OY-TES-1 Rabbit Polyclonal Antibody
别名
ACRBP; Acrosin-binding protein; Cancer/testis antigen 23; CT23; Cancer/testis antigen OY-TES-1; Proacrosin-binding protein sp32
蛋白名称
Acrosin-binding protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84519
Human Swissprot No.
Q8NEB7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NEB7/entry
Mouse Swissprot No.
Q3V140
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3V140
免疫原
The antiserum was produced against synthesized peptide derived from human ACRBP. AA range:181-230
特异性
OY-TES-1 Polyclonal Antibody detects endogenous levels of OY-TES-1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008],
组织表达
Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.
细胞定位
Secreted . Cytoplasmic vesicle, secretory vesicle, acrosome .
功能
function:May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.,PTM:Phosphorylated on Tyr residues in capacitated sperm.,PTM:The N-terminus is blocked.,subcellular location:Colocalizes with proacrosin in the acrosome of sperm.,subunit:Binds proacrosin.,tissue specificity:Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
