产品名称
OTUD2 Rabbit Polyclonal Antibody
别名
YOD1; DUBA8; HIN7; OTUD2; Ubiquitin thioesterase OTU1; DUBA-8; HIV-1-induced protease 7; HIN-7; HsHIN7; OTU domain-containing protein 2
蛋白名称
Ubiquitin thioesterase OTU1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55432
Human Swissprot No.
Q5VVQ6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5VVQ6/entry
Mouse Swissprot No.
Q8CB27
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CB27
免疫原
The antiserum was produced against synthesized peptide derived from human YOD1. AA range:116-165
特异性
OTUD2 Polyclonal Antibody detects endogenous levels of OTUD2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],
组织表达
Fetal liver,Spinal cord,Testis,
细胞定位
Cytoplasm . Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. .
信号通路
Limonene and pinene degradation;Biosynthesis of unsaturated fatty acids;
功能
function:Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.,sequence caution:Wrong choice of frame.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 OTU domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
