产品名称
Orexin R-1 Rabbit Polyclonal Antibody
别名
HCRTR1; Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1R; Hypocretin receptor type 1
蛋白名称
Orexin receptor type 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3061
Human Swissprot No.
O43613
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43613/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=230777
Mouse Swissprot No.
P58307
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P58307
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25593
Rat Swissprot Link
http://www.uniprot.org/uniprot/P56718
免疫原
The antiserum was produced against synthesized peptide derived from human HCRTR1. AA range:231-280
特异性
Orexin R-1 Polyclonal Antibody detects endogenous levels of Orexin R-1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009],
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
