产品名称
OPN Rabbit Polyclonal Antibody
别名
SPP1; BNSP; OPN; PSEC0156; Osteopontin; Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6696
Human Swissprot No.
P10451
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P10451/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20750
Mouse Swissprot No.
P10923
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P10923
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25353
Rat Swissprot Link
http://www.uniprot.org/uniprot/P08721
免疫原
The antiserum was produced against synthesized peptide derived from human Osteopontin. AA range:261-310
特异性
OPN Polyclonal Antibody detects endogenous levels of OPN protein.
稀释度
WB 1:500-2000;IHC-p 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
secreted phosphoprotein 1(SPP1) Homo sapiens The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
组织表达
Bone. Found in plasma.
信号通路
Focal adhesion;ECM-receptor interaction;Toll_Like;
功能
disease:This protein plays a principal role in urinary stone formation as the stone matrix.,function:Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.,function:Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.,online information:Osteopontin entry,PTM:Extensively phosphorylated on clustered serine residues.,PTM:N- and O-glycosylated.,similarity:Belongs to the osteopontin family.,subunit:Ligand for integrin alpha-V/beta-3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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