产品名称
INT7 Rabbit Polyclonal Antibody
别名
Integrator complex subunit 7 (Int7)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.258% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/25896
Human Swissprot No.
Q9NVH2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NVH2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/77065
Mouse Swissprot No.
Q7TQK1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TQK1
免疫原
Synthesized peptide derived from human INT7 AA range: 364-414
特异性
This antibody detects endogenous levels of INT7 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
细胞定位
Nucleus . Chromosome . Cytoplasm . Localizes to sites of DNA damage in a H2AX-independent manner.
功能
function:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.,sequence caution:Translated as Cys.,similarity:Belongs to the Integrator subunit 7 family.,subunit:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
