产品名称
ASB1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51665
Human Swissprot No.
Q9Y576
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y576/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/65247
Mouse Swissprot No.
Q9WV74
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WV74
免疫原
Synthesized peptide derived from human ASB1 AA range: 76-126
特异性
This antibody detects endogenous levels of ASB1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016],
功能
domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.,function:May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 SOCS box domain.,similarity:Contains 6 ANK repeats.,subunit:Interacts with CUL5 and RNF7.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
