产品名称
O-FucT-1 Rabbit Polyclonal Antibody
别名
POFUT1; FUT12; KIAA0180; GDP-fucose protein O-fucosyltransferase 1; Peptide-O-fucosyltransferase 1; O-FucT-1
蛋白名称
GDP-fucose protein O-fucosyltransferase 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23509
Human Swissprot No.
Q9H488
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H488/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140484
Mouse Swissprot No.
Q91ZW2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91ZW2
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=311551
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6EV70
免疫原
The antiserum was produced against synthesized peptide derived from human POFUT1. AA range:331-380
特异性
O-FucT-1 Polyclonal Antibody detects endogenous levels of O-FucT-1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
细胞定位
Endoplasmic reticulum .
功能
catalytic activity:Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.,cofactor:Manganese.,function:Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in EGF domains. Plays a crucial role in Notch signaling.,online information:GlycoGene database,online information:Peptide-O-fucosyltransferase 1,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 68 family.,tissue specificity:Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
