产品名称
OBCAM Rabbit Polyclonal Antibody
别名
OPCML; IGLON1; OBCAM; Opioid-binding protein/cell adhesion molecule; OBCAM; OPCML; Opioid-binding cell adhesion molecule; IgLON family member 1
蛋白名称
Opioid-binding protein/cell adhesion molecule
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4978
Human Swissprot No.
Q14982
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14982/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116597
Rat Swissprot Link
http://www.uniprot.org/uniprot/P32736
免疫原
The antiserum was produced against synthesized peptide derived from human OBCAM. AA range:152-201
特异性
OBCAM Polyclonal Antibody detects endogenous levels of OBCAM protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
组织表达
Amygdala,Brain,Fetal brain,Human amygdala,Occipital
细胞定位
Cell membrane ; Lipid-anchor, GPI-anchor .
功能
disease:Defects in OPCML are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome.,function:Binds opioids in the presence of acidic lipids; probably involved in cell contact.,similarity:Belongs to the immunoglobulin superfamily. IgLON family.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
