产品名称
OATP-C Rabbit Polyclonal Antibody
别名
SLCO1B1; LST1; OATP1B1; OATP2; OATPC; SLC21A6; Solute carrier organic anion transporter family member 1B1; Liver-specific organic anion transporter 1; LST-1; OATP-C; Sodium-independent organic anion-transporting polypeptide 2; OATP-2; Solut
蛋白名称
Solute carrier organic anion transporter family member 1B1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10599
Human Swissprot No.
Q9Y6L6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y6L6/entry
免疫原
The antiserum was produced against synthesized peptide derived from human SLCO1B1. AA range:251-300
特异性
OATP-C Polyclonal Antibody detects endogenous levels of OATP-C protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009],
组织表达
Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
细胞定位
Basolateral cell membrane ; Multi-pass membrane protein . Detected in basolateral membranes of hepatocytes.
功能
function:Mediates the Na(+)-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver.,similarity:Belongs to the organo anion transporter (TC 2.A.60) family.,subcellular location:Detected in basolateral membranes of hepatocytes.,tissue specificity:Highly expressed in liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
