产品名称
OAT Rabbit Polyclonal Antibody
别名
OAT; Ornithine aminotransferase; mitochondrial; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase
蛋白名称
Ornithine aminotransferase mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4942
Human Swissprot No.
P04181
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P04181/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18242
Mouse Swissprot No.
P29758
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P29758
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64313
Rat Swissprot Link
http://www.uniprot.org/uniprot/P04182
免疫原
Synthesized peptide derived from OAT . at AA range: 100-180
特异性
OAT Polyclonal Antibody detects endogenous levels of OAT protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
ornithine aminotransferase(OAT) Homo sapiens This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010],
组织表达
Alzheimer cortex,Brain,Cerebral cortex,Kidney,Liver,Placenta,Subthalamic nucleus,Ut
细胞定位
Mitochondrion matrix .
信号通路
Arginine and proline metabolism;
功能
catalytic activity:L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.,cofactor:Pyridoxal phosphate.,disease:Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:258870]. HOGA is a slowly progressive blinding autosomal recessive disorder.,pathway:Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.,similarity:Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homotetramer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
