产品名称
XPOT Rabbit Polyclonal Antibody
别名
Exportin-T (Exportin(tRNA)) (tRNA exportin)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.260% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11260
Human Swissprot No.
O43592
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43592/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/0
Mouse Swissprot No.
Q9CRT8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CRT8
免疫原
Synthesized peptide derived from human XPOT AA range: 135-185
特异性
This antibody detects endogenous levels of XPOT at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008],
组织表达
B-cell lymphoma,Cervix carcinoma,Lymph,Placenta,
细胞定位
Nucleus. Cytoplasm. Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.
功能
function:Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.,similarity:Belongs to the exportin family.,subcellular location:Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.,subunit:Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
