产品名称
NTR2 Rabbit Polyclonal Antibody
别名
NTSR2; Neurotensin receptor type 2; NT-R-2; NTR2; Levocabastine-sensitive neurotensin receptor
蛋白名称
Neurotensin receptor type 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23620
Human Swissprot No.
O95665
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95665/entry
Mouse Swissprot No.
P70310
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70310
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64636
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63384
免疫原
The antiserum was produced against synthesized peptide derived from human NTR2. AA range:151-200
特异性
NTR2 Polyclonal Antibody detects endogenous levels of NTR2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008],
组织表达
Expressed in prostate (at protein level).
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.,online information:Neurotensin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
