产品名称
NT5C1A Rabbit Polyclonal Antibody
别名
NT5C1A; Cytosolic 5'-nucleotidase 1A; cN1A; Cytosolic 5'-nucleotidase IA; cN-I; cN-IA
蛋白名称
Cytosolic 5'-nucleotidase 1A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84618
Human Swissprot No.
Q9BXI3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9BXI3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=230718
Mouse Swissprot No.
A3KFX0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A3KFX0
免疫原
The antiserum was produced against synthesized peptide derived from human NT5C1A. AA range:151-200
特异性
NT5C1A Polyclonal Antibody detects endogenous levels of NT5C1A protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008],
组织表达
Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.
信号通路
Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;
功能
catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Magnesium.,enzyme regulation:Activated by ADP.,function:Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.,similarity:Belongs to the 5'-nucleotidase type 3 family.,tissue specificity:Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
