产品名称
Nrl Rabbit Polyclonal Antibody
别名
NRL; D14S46E; Neural retina-specific leucine zipper protein; NRL
蛋白名称
Neural retina-specific leucine zipper protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4901
Human Swissprot No.
P54845
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P54845/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18185
Mouse Swissprot No.
P54846
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P54846
免疫原
The antiserum was produced against synthesized peptide derived from human NRL. AA range:19-68
特异性
Nrl Polyclonal Antibody detects endogenous levels of Nrl protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the brain and the retina (PubMed:11477108). Expressed strongly in rod and cone cells (at protein level) (PubMed:11477108).
细胞定位
Cytoplasm . Nucleus .
功能
disease:Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27) [MIM:162080]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant.,function:Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subunit:Interacts with FIZ1. This interaction represses transactivation.,tissue specificity:Neural retina.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
