BD-PT3189

Nrf2 Rabbit Polyclonal Antibody

NFE2L2; NRF2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor; erythroid derived 2, like 2

常规抗体

NFE2L2

Nuclear factor erythroid 2-related factor 2

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

4780

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4780

Q16236

http://www.uniprot.org/uniprotkb/Q16236/entry

18024

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18024

Q60795

http://www.uniprot.org/uniprot/Q60795

83619

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83619

O54968

http://www.uniprot.org/uniprot/O54968

The antiserum was produced against synthesized peptide derived from human Nrf2. AA range:556-605

Nrf2 Polyclonal Antibody detects endogenous levels of Nrf2 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

75-100kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015],

Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

Cytoplasm, cytosol . Nucleus . Cytosolic under unstressed conditions: ubiquitinated and degraded by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:15601839, PubMed:21196497). Translocates into the nucleus upon induction by electrophilic agents that inactivate the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:21196497). .

domain:Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.,function:Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.,PTM:Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. CNC subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.,subunit:Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.,tissue specificity:Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.