产品名称
NRF-1 Rabbit Polyclonal Antibody
别名
NRF1; Nuclear respiratory factor 1; NRF-1; Alpha palindromic-binding protein; Alpha-pal
蛋白名称
Nuclear respiratory factor 1
反应种属
Human,Mouse,Rat,Bovine
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4899
Human Swissprot No.
Q16656
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16656/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18181
Mouse Swissprot No.
Q9WU00
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WU00
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q62792
免疫原
The antiserum was produced against synthesized peptide derived from human NRF1. AA range:221-270
特异性
NRF-1 Polyclonal Antibody detects endogenous levels of NRF-1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014],
组织表达
Ubiquitously expressed with strongest expression in skeletal muscle.
信号通路
Huntington's disease;
功能
function:Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.,PTM:Phosphorylation enhances DNA binding.,similarity:Belongs to the NRF1/Ewg family.,subunit:Homodimer. Binds DNA as a dimer. Interacts with PPRC1.,tissue specificity:Ubiquitously expressed with strongest expression in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
