产品名称
NPY5-R Rabbit Polyclonal Antibody
别名
NPY5R; NPYR5; Neuropeptide Y receptor type 5; NPY5-R; NPY-Y5 receptor; NPYY5-R; Y5 receptor
蛋白名称
Neuropeptide Y receptor type 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4889
Human Swissprot No.
Q15761
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15761/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18168
Mouse Swissprot No.
O70342
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70342
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25340
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63634
免疫原
The antiserum was produced against synthesized peptide derived from human NPY5R. AA range:221-270
特异性
NPY5-R Polyclonal Antibody detects endogenous levels of NPY5-R protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015],
组织表达
Brain; hypothalamus.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Brain; hypothalamus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
