产品名称
NPY1-R Rabbit Polyclonal Antibody
别名
NPY1R; NPYR; NPYY1; Neuropeptide Y receptor type 1; NPY1-R
蛋白名称
Neuropeptide Y receptor type 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4886
Human Swissprot No.
P25929
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P25929/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18166
Mouse Swissprot No.
Q04573
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q04573
Rat Swissprot Link
http://www.uniprot.org/uniprot/P21555
免疫原
The antiserum was produced against synthesized peptide derived from human NPY1R. AA range:221-270
特异性
NPY1-R Polyclonal Antibody detects endogenous levels of NPY1-R protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013],
组织表达
Blood,Brain,Pancreas,Testis,
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
