产品名称
NPY Rabbit Polyclonal Antibody
别名
NPY; Pro-neuropeptide Y
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4852
Human Swissprot No.
P01303
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P01303/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=109648
Mouse Swissprot No.
P57774
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P57774
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100912228
Rat Swissprot Link
http://www.uniprot.org/uniprot/P07808
免疫原
The antiserum was produced against synthesized peptide derived from human NPY. AA range:45-94
特异性
NPY Polyclonal Antibody detects endogenous levels of NPY protein.
稀释度
IHC-p 1:100-500，WB 1:500-2000,ELISA 1:5000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014],
组织表达
One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
细胞定位
Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle .
功能
function:NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.,online information:Neuropeptide Y entry,similarity:Belongs to the NPY family.,tissue specificity:One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
