产品名称
NMDAε4 Rabbit Polyclonal Antibody
别名
GRIN2D; GluN2D; NMDAR2D; Glutamate [NMDA] receptor subunit epsilon-4; EB11; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D
蛋白名称
Glutamate [NMDA] receptor subunit epsilon-4
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2906
Human Swissprot No.
O15399
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O15399/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14814
Mouse Swissprot No.
Q03391
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q03391
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24412
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q62645
免疫原
The antiserum was produced against synthesized peptide derived from human GRIN2D. AA range:671-720
特异性
NMDAε4 Polyclonal Antibody detects endogenous levels of NMDAε4 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010],
细胞定位
Cell membrane ; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
信号通路
Calcium;Neuroactive ligand-receptor interaction;Long-term potentiation;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);
功能
function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
