产品名称
NMBR Rabbit Polyclonal Antibody
别名
NMBR; Neuromedin-B receptor; NMB-R; Epididymis tissue protein Li 185a; Neuromedin-B-preferring bombesin receptor
蛋白名称
Neuromedin-B receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4829
Human Swissprot No.
P28336
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P28336/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18101
Mouse Swissprot No.
O54799
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54799
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25264
Rat Swissprot Link
http://www.uniprot.org/uniprot/P24053
免疫原
The antiserum was produced against synthesized peptide derived from human NMBR. AA range:221-270
特异性
NMBR Polyclonal Antibody detects endogenous levels of NMBR protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016],
组织表达
Expressed in epididymis (at protein level).
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for neuromedin-B.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
