产品名称
Nkx-3.1 Rabbit Polyclonal Antibody
别名
NKX3-1; NKX3.1; NKX3A; Homeobox protein Nkx-3.1; Homeobox protein NK-3 homolog A
蛋白名称
Homeobox protein Nkx-3.1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4824
Human Swissprot No.
Q99801
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99801/entry
Mouse Swissprot No.
P97436
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97436
免疫原
The antiserum was produced against synthesized peptide derived from human NKX3-1. AA range:1-50
特异性
Nkx-3.1 Polyclonal Antibody detects endogenous levels of Nkx-3.1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012],
组织表达
Highly expressed in the prostate and, at a lower level, in the testis.
信号通路
Pathways in cancer;Prostate cancer;
功能
alternative products:Additional isoforms seem to exist,disease:NKX3-1 has been thought to be one of the target gene of the 8p21 loss of heterozygosity, common in prostate cancer, but neither disruption of the coding region of the gene, nor mutations have been found in prostate cancer.,function:Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Could play an important role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate.,induction:By androgens and, in the LNCAP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen-independent phase.,similarity:Belongs to the NK-3 homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77.,tissue specificity:Highly expressed in the prostate and, at a lower level, in the testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
